The BCS (Basic Chemical Space) Screen developed at theStructural Genomic Consortium (SGC), Oxfordhas a novel approach to screening. PEGs are grouped by molecular weight and mixed to create fourPEG Smears*(available to purchase separately). The Smears cover a broader range of chemical space while reducing the number of PEG variables.The benefit of using PEG smears is that it reduces the number of PEG variables while maintaining a large coverage of PEG space.

The bottom line is that in tests at the SGC with 191 human proteins, the BCS Screen had a 42% hit rate with only 96 conditions. Many of these proteins had failed to crystallize in other screens.

牛津大学结构基因组联盟(SGC)开发的BCS(基本化学空间)筛选有一种新颖的筛选方法。PEG按分子量分组并混合以创建四个PEG涂片*(可单独购买)。涂片覆盖了更广泛的化学空间，同时减少了PEG变量的数量。使用PEG涂片的好处是，它减少了PEG变量的数量，同时保持了较大的PEG空间覆盖率。

底线是，在SGC对191种人类蛋白质的测试中，BCS筛选在仅96种条件下的命中率为42%。这些蛋白质中有许多在其他筛选中无法结晶。