Anti-HFE2PolyclonalAntibody-一抗-抗体-蛋白与免疫-耗材-金山科研平台 Bio-Rad伯乐官网 |伯乐授权代理 |伯乐ddPCR| 伯乐Aminex| 伯乐层析填料色谱柱

Anti-HFE2PolyclonalAntibody-一抗-抗体-蛋白与免疫

2023-10-29

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Anti-HFE2 Polyclonal Antibody品牌：solarbio | 货号：K003928P

英文名称	Anti-HFE2 Polyclonal Antibody
宿主	Rabbit
别名	HFE2A;HJV;JH;RGMC
应用	WB
稀释比例	WB 1:500-2000.
交叉反应	Human Rat
蛋白分子量	45kDa
Gene ID	148738
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	Recombinant protein of human HFE2
性状	液体
Public Immunogen Range	Recombinant protein of human HFE2
Subcellular Locations	Cell membrane GPI-anchor Lipid-anchor
Swiss Prot	Q6ZVN8
克隆类型	Polyclonal Antibody
背景资料	The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5′ UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.

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