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Anti-Phospho-NFκBp105-S927PolyclonalAntibody-一抗-抗体-蛋白与免疫

2023-10-29

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Anti-Phospho-NFκB p105-S927 Polyclonal Antibody

英文名称	Rabbit Phospho-NFκB p105-S927 Polyclonal Antibody
应用2	WB
克隆类型2	Polyclonal Antibody
别名	CVID12;EBP-1;KBF1;NF-kB1;NF-kappa-B;NF-kappaB;NFKB-p105;NFKB-p50;NFkappaB;p105;p50
应用	WB
稀释比例	WB1:500-1:1000
交叉反应	Human
蛋白分子量	105kDa
Gene ID	4790
保存	Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment.
储存液	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	A phospho specific peptide corresponding to residues surrounding S927 of human NFκB p105
性状	Lyophilized or Liquid
Swiss Prot	P19838
克隆类型	Polyclonal Antibody
来源	Rabbit
背景资料	This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.

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