Anti-NOTCH4PolyclonalAntibody-一抗-抗体-蛋白与免疫

2023-10-29

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Anti-NOTCH4 Polyclonal Antibody品牌:solarbio | 货号:K005743P

英文名称Anti-NOTCH4 Polyclonal Antibody
宿主Rabbit
别名INT3
应用WB
稀释比例WB 1:500-2000.
交叉反应 Human Mouse Rat
蛋白分子量210kDa
Gene ID4855
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG
免疫原Recombinant protein of human NOTCH4
性状液体
Public Immunogen RangeRecombinant protein of human NOTCH4
Subcellular LocationsCell membrane Nucleus Single-pass type I membrane protein
Swiss ProtQ99466
克隆类型 Polyclonal Antibody
背景资料This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

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