Anti-RPE65PolyclonalAntibody-一抗-抗体-蛋白与免疫

2023-10-29

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Anti-RPE65 Polyclonal Antibody品牌:solarbio | 货号:K006081P

英文名称Anti-RPE65 Polyclonal Antibody
宿主Rabbit
别名BCO3;LCA2;RP20;mRPE65;rd12;sRPE65
应用WB
稀释比例WB 1:500-2000.
交叉反应 Human Mouse Rat
蛋白分子量61kDa
Gene ID6121
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG
免疫原Recombinant protein of human RPE65
性状液体
Public Immunogen RangeRecombinant protein of human RPE65
Subcellular LocationsCell membrane Cytoplasm Lipid-anchor Microsome membrane
Swiss ProtQ16518
克隆类型 Polyclonal Antibody
背景资料This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa.

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