Anti-ERBB3PolyclonalAntibody-一抗-抗体-蛋白与免疫

2023-10-29

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Anti-ERBB3 Polyclonal Antibody品牌:solarbio | 货号:K006703P

英文名称Anti-ERBB3 Polyclonal Antibody
宿主Rabbit
别名HER3;LCCS2;ErbB-3;c-erbB3;erbB3-S;MDA-BF-1;c-erbB-3;p180-ErbB3;p45-sErbB3;p85-sErbB3
应用IHC
稀释比例IHC 1:50-150.
交叉反应 Human Mouse Rat
蛋白分子量148kDa
Gene ID2065
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG
免疫原Recombinant protein of human ERBB3
性状液体
Public Immunogen RangeRecombinant protein of human ERBB3
Subcellular LocationsCytoplasm Cell membrane
Swiss ProtP21860
克隆类型 Polyclonal Antibody
背景资料This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

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