Anti-MSH6PolyclonalAntibody-一抗-抗体-蛋白与免疫

2023-10-29

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Anti-MSH6 Polyclonal Antibody品牌:solarbio | 货号:K003624P

英文名称Anti-MSH6 Polyclonal Antibody
宿主Rabbit
别名GTBP;GTMBP;HNPCC5;HSAP;p160
应用WB IF
稀释比例WB 1:500-1000. IF 1:50-100.
交叉反应 Human Mouse
蛋白分子量153kDa
Gene ID2956
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG
免疫原Recombinant protein of human MSH6
性状液体
Public Immunogen RangeRecombinant protein of human MSH6
Subcellular LocationsNucleus
Swiss ProtP52701
克隆类型 Polyclonal Antibody
背景资料This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.

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