Anti-BBS10PolyclonalAntibody-一抗-抗体-蛋白与免疫
2023-10-29
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Anti-BBS10 Polyclonal Antibody品牌：solarbio | 货号：K005974P| 英文名称 | Anti-BBS10 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | C12orf58 |
| 应用 | WB |
| 稀释比例 | WB 1:200-3000. |
| 交叉反应 | Human Mouse |
| 蛋白分子量 | 81kDa |
| Gene ID | 79738 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human BBS10 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human BBS10 |
| Subcellular Locations | Cell projection cilium |
| Swiss Prot | Q8TAM1 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein’s expression impairs ciliogenesis in preadipocytes. Mutations in this gene cause Bardet-Biedl syndrome type 10. |
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