Anti-DUSP12PolyclonalAntibody-一抗-抗体-蛋白与免疫
2023-10-29
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Anti-DUSP12 Polyclonal Antibody品牌：solarbio | 货号：K006740P| 英文名称 | Anti-DUSP12 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | YVH1;DUSP1 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:200-1000. IHC 1:25-100. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 38kDa |
| Gene ID | 11266 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human DUSP12 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human DUSP12 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | Q9UNI6 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. |
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