Anti-ATMPolyclonalAntibody-一抗-抗体-蛋白与免疫

2023-10-29

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Anti-ATM Polyclonal Antibody品牌:solarbio | 货号:K004295P

英文名称Anti-ATM Polyclonal Antibody
宿主Rabbit
别名AT1;ATA;ATC;ATD;ATDC;ATE;TEL1;TELO1
应用WB
稀释比例WB 1:500-1000.
交叉反应 Human
蛋白分子量351kDa
Gene ID472
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG
免疫原A synthetic peptide of human ATM
性状液体
Public Immunogen RangeA synthetic peptide of human ATM
Subcellular LocationsCytoplasmic vesicle Nucleus
Swiss ProtQ13315
克隆类型 Polyclonal Antibody
背景资料The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

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