Anti-IMPA1PolyclonalAntibody-一抗-抗体-蛋白与免疫

2023-10-29

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Anti-IMPA1 Polyclonal Antibody品牌:solarbio | 货号:K007314P

英文名称Anti-IMPA1 Polyclonal Antibody
宿主Rabbit
别名IMP;IMPA
应用WB IHC
稀释比例WB 1:500-2000. IHC 1:25-100.
交叉反应 Human Mouse Rat
蛋白分子量30kDa
Gene ID3612
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG
免疫原Recombinant protein of human IMPA1
性状液体
Public Immunogen RangeRecombinant protein of human IMPA1
Subcellular LocationsCytoplasm Nucleus
Swiss ProtP29218
克隆类型 Polyclonal Antibody
背景资料This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2′-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.

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