Anti-HRASPolyclonalAntibody-一抗-抗体-蛋白与免疫

2023-10-29

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Anti-HRAS Polyclonal Antibody品牌:solarbio | 货号:K007381P

英文名称Anti-HRAS Polyclonal Antibody
宿主Rabbit
别名CTLO;HAMSV;HRAS1;RASH1;p21ras;C-H-RAS;H-RASIDX;C-BAS/HAS;C-HA-RAS1
应用WB IHC
稀释比例WB 1:500-2000. IHC 1:25-50.
交叉反应 Human Mouse Rat
蛋白分子量21kDa
Gene ID3265
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG
免疫原A synthetic peptide of human HRAS
性状液体
Public Immunogen RangeA synthetic peptide of human HRAS
Subcellular LocationsCytoplasm
Swiss ProtP01112
克隆类型 Polyclonal Antibody
背景资料This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.

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