Anti-DUSP4PolyclonalAntibody-一抗-抗体-蛋白与免疫

2023-10-29

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Anti-DUSP4 Polyclonal Antibody品牌:solarbio | 货号:K008150P

英文名称Anti-DUSP4 Polyclonal Antibody
宿主Rabbit
别名TYP;HVH2;MKP2;MKP-2
应用WB IHC
稀释比例WB 1:500-2000. IHC 1:50-150.
交叉反应 Human Mouse Rat
蛋白分子量43kDa
Gene ID1846
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG
免疫原Recombinant protein of human DUSP4
性状液体
Public Immunogen RangeRecombinant protein of human DUSP4
Subcellular LocationsCytoplasm Nucleus
Swiss ProtQ13115
克隆类型 Polyclonal Antibody
背景资料The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.

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