Anti-SPATA13PolyclonalAntibody-一抗-抗体-蛋白与免疫-耗材-金山科研平台 Bio-Rad伯乐官网 |伯乐授权代理 |伯乐ddPCR| 伯乐Aminex| 伯乐层析填料色谱柱

Anti-SPATA13PolyclonalAntibody-一抗-抗体-蛋白与免疫

2023-10-29

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Anti-SPATA13 Polyclonal Antibody品牌：solarbio | 货号：K006838P

英文名称	Anti-SPATA13 Polyclonal Antibody
宿主	Rabbit
别名	ASEF2;ARHGEF29;RP11-307N16.3
应用	WB IHC
稀释比例	WB 1:200-1000. IHC 1:25-100.
交叉反应	Human Mouse
蛋白分子量	75kDa
Gene ID	221178
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	Recombinant protein of human SPATA13
性状	液体
Public Immunogen Range	Recombinant protein of human SPATA13
Subcellular Locations	Cytoplasm
Swiss Prot	Q96N96
克隆类型	Polyclonal Antibody
背景资料	Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. Both the ABR and the SH3 domains contribute to maintaining the protein in an inhibited conformation by associating with the C-terminal tail. Binding of these domains to the C-terminal tail inhibits the activity of the protein by blocking a region that is required for its GEF activity.

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