Anti-FUBP1PolyclonalAntibody-一抗-抗体-蛋白与免疫

2023-10-29

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Anti-FUBP1 Polyclonal Antibody品牌:solarbio | 货号:K004075P

英文名称Anti-FUBP1 Polyclonal Antibody
宿主Rabbit
别名FBP;FUBP;hDH V
应用WB IHC IP
稀释比例WB 1:500-2000. IHC 1:50-200. IP 1:50-100.
交叉反应 Human Mouse
蛋白分子量68kDa
Gene ID8880
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG
免疫原Recombinant protein of human FUBP1
性状液体
Public Immunogen RangeRecombinant protein of human FUBP1
Subcellular LocationsNucleus
Swiss ProtQ96AE4
克隆类型 Polyclonal Antibody
背景资料The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3′-5′ helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants.

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