Anti-SART1PolyclonalAntibody-一抗-抗体-蛋白与免疫
2023-10-29
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Anti-SART1 Polyclonal Antibody品牌：solarbio | 货号：K005919P| 英文名称 | Anti-SART1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | Ara1;HOMS1;SART1259;SNRNP110;Snu66 |
| 应用 | WB IP |
| 稀释比例 | WB 1:500-2000. IP 1:20-50. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 90kDa |
| Gene ID | 9092 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human SART1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human SART1 |
| Subcellular Locations | Nucleus |
| Swiss Prot | O43290 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. |
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