Anti-BCCIPPolyclonalAntibody-一抗-抗体-蛋白与免疫
2023-10-29
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Anti-BCCIP Polyclonal Antibody品牌：solarbio | 货号：K005929P| 英文名称 | Anti-BCCIP Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | TOK-1;TOK1 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:100-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 36kDa |
| Gene ID | 56647 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human BCCIP |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human BCCIP |
| Subcellular Locations | Nucleus |
| Swiss Prot | Q9P287 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. |
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