Anti-PRKAR2APolyclonalAntibody-一抗-抗体-蛋白与免疫

2023-10-29

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Anti-PRKAR2A Polyclonal Antibody品牌:solarbio | 货号:K007141P

英文名称Anti-PRKAR2A Polyclonal Antibody
宿主Rabbit
别名PKR2;PRKAR2
应用WB IHC
稀释比例WB 1:500-2000. IHC 1:35-200.
交叉反应 Human
蛋白分子量46kDa
Gene ID5576
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG
免疫原Recombinant protein of human PRKAR2A
性状液体
Public Immunogen RangeRecombinant protein of human PRKAR2A
Subcellular LocationsCytoplasm Cell membrane
Swiss ProtP13861
克隆类型 Polyclonal Antibody
背景资料cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).

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