品牌: wanleibio 公司: 沈阳万类生物科技有限公司

货号： WL02093 抗体名： SREBP-1抗体 抗体英文名： SREBP-1 antibody 浓度： >1mg/ml 应用范围： WB,IHC 宿主： 兔 适应物种： H,M,R 标记物： 无 克隆性： 否 保存条件： -20℃ 形态： 液体 亚型： IgG 规格： 50μl(>50μg)

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本公司所有一抗，50μl(>50μg)装只卖899.00元

产品货号WL02093产品名称SREBP-1 Antibody预测分子量mature SREBP-1 p68: 68kDaSREBP-1 p125 precursor : 125kDa别名ADD 1; bHLHd1; SREBF 1; SREBP1; Sterol regulatory element binding protein 1浓度＞1 mg/ml免疫原合成SREBP-1多肽抗体来源兔特异性抗人、小鼠、大鼠克隆类型多克隆抗体产品应用WB；IHC成分亲和纯化抗体，20 mM PBS，150 mM NaCl，100 μg/ml BSA，50%甘油，NaN₃<0.02%保存条件-20℃保存背景资料Sterol regulatory element–binding proteins (SREBPs) are basic helix-loop-helix–leucine zipper transcription factors, including SREBP-1 and SREBP-2. SREBP-1 is synthesized as a precursor that is attached to the nuclear envelope and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription.Among the isoforms of SREBPs, SREBP-1c activates all lipogenic genes in the liver. Phosphorylation of SREBP-1c at Ser372 by AMPK ihibits the proteolytic cleavage of SREBP-1c and therefore suppresses the expression of its target genes in the liver.

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