The BCS (Basic Chemical Space) Screen developed at theStructural Genomic Consortium (SGC), Oxfordhas a novel approach to screening. PEGs are grouped by molecular weight and mixed to create fourPEG Smears*(available to purchase separately). The Smears cover a broader range of chemical space while reducing the number of PEG variables.The benefit of using PEG smears is that it reduces the number of PEG variables while maintaining a large coverage of PEG space.

The bottom line is that in tests at the SGC with 191 human proteins, the BCS Screen had a 42% hit rate with only 96 conditions. Many of these proteins had failed to crystallize in other screens.

PEG Smears for broader chemical space coverage

牛津大学结构基因组联盟(SGC)开发的BCS(基本化学空间)筛选有一种新颖的筛选方法。PEG按分子量分组并混合以创建四个PEG涂片*(可单独购买)。涂片覆盖了更广泛的化学空间，同时减少了PEG变量的数量。使用PEG涂片的好处是，它减少了PEG变量的数量，同时保持了较大的PEG空间覆盖率。

底线是，在SGC对191种人类蛋白质的测试中，BCS筛选在仅96种条件下的命中率为42%。这些蛋白质中有许多在其他筛选中无法结晶。

MD1-104The BCS Screen96 x 10 ml

MD1-104-ECOThe BCS Eco Screen96 x 10 ml

MD1-105The BCS Screen HT-9696 x 1 mlMD1-105-ECOThe BCS Screen HT-96 Eco Screen96 x 1 mlMD1-105-FXThe BCS Screen FX pre-filled plate96 x 100 µlMD2-100-25850% v/v PEG Smear Low (100ml)100 ml

MD2-100-25950% v/v PEG Smear Medium (100ml)100 ml

MD2-100-26050% v/v PEG Smear High (100ml)100 mlMD2-100-26150% v/v PEG Smear Broad (100ml)100 ml

MD2-250-25850% v/v PEG Smear Low (250ml)250 mlMD2-250-25950% v/v PEG Smear Medium (250ml)250 ml

MD2-250-26050% v/v PEG Smear High (250ml)250 ml

MD2-250-26150% v/v PEG Smear Broad (250ml)250 mlMDSR-104-The BCS Screen Single Reagent100 mlMDSR-104-ECO-The BCS Eco Screen Single Reagent100 ml

MDSR-105-The BCS Screen HT-96 Single Reagent100 mlMDSR-105-ECO-The BCS Eco Screen HT-96 Single Reagent100 ml

Product #	Product Name	Unit Size	Unit Price