SiliaBond^®羧酸 (Si-CAA) 可用作胺类或碳酸盐的清除剂，以及醇盐和有机金属试剂的淬灭剂。

SiliaBondCarboxylic Acid is primarily used as a weak cation exchanger (WCX) in solid phase extraction (SPE) and in HPLC. It is preferred overSiliaBondTosic Acid(SCX) when performing “Catch and Release” purification technique of compounds bearing a permanent positive charge such as tetraalkylammoniums. Using the SCX in this case could make the release of the compound of interest difficult, not to say irreversible, due to the strong interaction between the two strong ioins.SiliaBondCarboxylic Acid has a pka of ≈4.5. It can also be used in ion exchange chromatography (IEC) and has a different selectivity thanSiliaBondTosic Acid (SCX).^1,2