Anti-Phospho-ALOX5-S271PolyclonalAntibody-一抗-抗体-蛋白与免疫
2023-10-29
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Anti-Phospho-ALOX5-S271 Polyclonal Antibody品牌：solarbio | 货号：K006242P| 英文名称 | Anti-Phospho-ALOX5-S271 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | 5-LO;5-LOX;5LPG;LOG5 |
| 应用 | WB |
| 稀释比例 | WB 1:500-2000. |
| 交叉反应 | Human |
| 蛋白分子量 | 78kDa |
| Gene ID | 240 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A phospho specific peptide corresponding to residues surrounding S271 of human ALOX5 |
| 性状 | 液体 |
| Public Immunogen Range | A phospho specific peptide corresponding to residues surrounding S271 of human ALOX5 |
| Subcellular Locations | Cytoplasm Nucleus matrix Nucleus membrane Peripheral membrane protein |
| Swiss Prot | P09917 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
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