Anti-SMAD2PolyclonalAntibody-一抗-抗体-蛋白与免疫
2023-10-29
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Anti-SMAD2 Polyclonal Antibody品牌：solarbio | 货号：K005398P| 英文名称 | Anti-SMAD2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | JV18;JV18-1;MADH2;MADR2;hMAD-2;hSMAD2 |
| 应用 | WB IHC IF |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. IF 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 52kDa |
| Gene ID | 4087 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of human SMAD2 |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human SMAD2 |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | Q15796 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene ‘mothers against decapentaplegic’ (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. |
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