Anti-SIRPAPolyclonalAntibody-一抗-抗体-蛋白与免疫

2023-10-29

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Anti-SIRPA Polyclonal Antibody品牌:solarbio | 货号:K005985P

英文名称Anti-SIRPA Polyclonal Antibody
宿主Rabbit
别名BIT;CD172A;MFR;MYD-1;P84;PTPNS1;SHPS1;SIRP
应用WB
稀释比例WB 1:500-2000.
交叉反应 Human Mouse Rat
蛋白分子量55kDa
Gene ID140885
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG
免疫原Recombinant protein of human SIRPA
性状液体
Public Immunogen RangeRecombinant protein of human SIRPA
Subcellular LocationsMembrane Single-pass type I membrane protein
Swiss ProtP78324
克隆类型 Polyclonal Antibody
背景资料The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.

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