Anti-GSTA2PolyclonalAntibody-一抗-抗体-蛋白与免疫

2023-10-29

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Anti-GSTA2 Polyclonal Antibody品牌:solarbio | 货号:K005386P

英文名称Anti-GSTA2 Polyclonal Antibody
宿主Rabbit
别名GST2;GSTA2-2;GTA2;GTH2
应用WB IHC
稀释比例WB 1:500-2000. IHC 1:50-200.
交叉反应 Human Mouse Rat
蛋白分子量26kDa
Gene ID2939
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG
免疫原Recombinant protein of human GSTA2
性状液体
Public Immunogen RangeRecombinant protein of human GSTA2
Subcellular LocationsCytoplasm
Swiss ProtP09210
克隆类型 Polyclonal Antibody
背景资料Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual’s susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.

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