Anti-VRK1PolyclonalAntibody-一抗-抗体-蛋白与免疫
2023-10-29
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Anti-VRK1 Polyclonal Antibody品牌：solarbio | 货号：K005435P| 英文名称 | Anti-VRK1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | PCH1;PCH1A |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 45kDa |
| Gene ID | 7443 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human VRK1 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human VRK1 |
| Subcellular Locations | Cytoplasm Nucleus cytoskeleton spindle |
| Swiss Prot | Q99986 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. |
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