Anti-Phospho-BRCA1-S988PolyclonalAntibody-一抗-抗体-蛋白与免疫
2023-10-29
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Anti-Phospho-BRCA1-S988 Polyclonal Antibody品牌：solarbio | 货号：K006215P| 英文名称 | Anti-Phospho-BRCA1-S988 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | BRCAI;BRCC1;BROVCA1;FANCS;IRIS;PNCA4;PPP1R53;PSCP;RNF53 |
| 应用 | WB IF |
| 稀释比例 | WB 1:500-2000. IF 1:50-200. |
| 交叉反应 | Human |
| 蛋白分子量 | 208kDa |
| Gene ID | 672 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A phospho specific peptide corresponding to residues surrounding S988 of human BRCA1 |
| 性状 | 液体 |
| Public Immunogen Range | A phospho specific peptide corresponding to residues surrounding S988 of human BRCA1 |
| Subcellular Locations | Chromosome Cytoplasm Cytoplasm Nucleus |
| Swiss Prot | P38398 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. |
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