Anti-ARID1APolyclonalAntibody-一抗-抗体-蛋白与免疫

2023-10-29

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Anti-ARID1A Polyclonal Antibody品牌:solarbio | 货号:K007650P

英文名称Anti-ARID1A Polyclonal Antibody
宿主Rabbit
别名ELD;B120;OSA1;P270;hELD;BM029;MRD14;hOSA1;BAF250;C1orf4;BAF250a;SMARCF1
应用IHC
稀释比例IHC 1:50-200.
交叉反应 Human Mouse
蛋白分子量242/218/206kDa
Gene ID8289
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG
免疫原A synthetic peptide of human ARID1A
性状液体
Public Immunogen RangeA synthetic peptide of human ARID1A
Subcellular LocationsNucleus
Swiss ProtO14497
克隆类型 Polyclonal Antibody
背景资料This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions.

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