Anti-EGLN3PolyclonalAntibody-一抗-抗体-蛋白与免疫
2023-10-29
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Anti-EGLN3 Polyclonal Antibody品牌：solarbio | 货号：K008225P| 英文名称 | Anti-EGLN3 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | PHD3;HIFPH3;HIFP4H3 |
| 应用 | WB |
| 稀释比例 | WB 1:200-1000. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 27kDa |
| Gene ID | 112399 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human EGLN3 |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human EGLN3 |
| Swiss Prot | Q9H6Z9 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM in hypoxia, limiting glycolysis. Under normoxia, hydroxylates and regulates the stability of ADRB2. Regulator of cardiomyocyte and neuronal apoptosis. |
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