Anti-CDKL1PolyclonalAntibody-一抗-抗体-蛋白与免疫

2023-10-29

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Anti-CDKL1 Polyclonal Antibody品牌:solarbio | 货号:K007997P

英文名称Anti-CDKL1 Polyclonal Antibody
宿主Rabbit
别名P42;KKIALRE
应用WB IHC
稀释比例WB 1:200-1000. IHC 1:20-100.
交叉反应 Human
蛋白分子量42kDa
Gene ID8814
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG
免疫原A synthetic peptide of human CDKL1
性状液体
Public Immunogen RangeA synthetic peptide of human CDKL1
Subcellular LocationsCytoplasm Nucleus
Swiss ProtQ00532
克隆类型 Polyclonal Antibody
背景资料The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated by the MAP kinases ERK 1 and ERK 2. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites mapping within a characteristic Thr-Glu-Tyr motif. The protein kinase p56 KKIAMRE is distantly related to the MAP kinase group of proteins and is closely related to p42 KKIALRE. KKIAMRE is predominantly expressed in testis, kidney, brain and lung. KKIAMRE contains the conserved MAP kinase dual phosphorylation motif in the sequence Thr-Asp-Tyr and is activated by treatment of cells by EGF. However, unlike other MAP kinases, the EGF-stimulated kinase activity does not require phosphorylation of KKIAMRE and KKIALRE in the Thr-Asp-Tyr motif.

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